Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0CO6T
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| Former ID |
DNC006149
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| Drug Name |
NAPHTHYRIDINONE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [530929] | ||
| Structure |
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Download2D MOL |
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| Formula |
C25H18Cl3N3O3
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| Canonical SMILES |
CC(=O)C1=C(C2=CC(=C(N=C2N(C1=O)C)C3=C(C=C(C=C3)Cl)Cl)C4<br />=CC=C(C=C4)Cl)NC(=O)C
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| InChI |
1S/C25H18Cl3N3O3/c1-12(32)21-23(29-13(2)33)19-11-18(14-4-6-15(26)7-5-14)22(30-24(19)31(3)25(21)34)17-9-8-16(27)10-20(17)28/h4-11H,1-3H3,(H,29,33)
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| InChIKey |
VHSIAYLBCLUAFT-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cannabinoid receptor 2 | Target Info | Inhibitor | [527839] | |
| Cannabinoid receptor 1 | Target Info | Inhibitor | [530929] | ||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| Pathway Interaction Database | N-cadherin signaling events | ||||
| References | |||||
| Ref 527839 | Bioorg Med Chem Lett. 2006 Feb;16(3):681-5. Epub 2005 Nov 2.Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists. | ||||
| Ref 530929 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. Epub 2010 Apr 21.Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. | ||||
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