Drug General Information
Drug ID	D0CV7T
Former ID	DIB015873
Drug Name	Patamostat
Synonyms	E-3123
Drug Type	Small molecular drug
Indication	Hypotension [ICD9: 458, 796.3; ICD10:I95]		Terminated	[545400]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C20H20N4O4S
Canonical SMILES	N1(C(=O)CCC1=O)CCSc1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1.S(=<br />O)(=O)(O)C
CAS Number	CAS 114568-32-0
PubChem Compound ID	65921
Target and Pathway
Target(s)	Trypsin	Target Info	Modulator	[533452], [549592], [550162]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Pancreatic secretion
	Protein digestion and absorption
	Influenza A
Reactome	Activation of Matrix Metalloproteinases
	Cobalamin (Cbl, vitamin B12) transport and metabolism
WikiPathways	Activation of Matrix Metalloproteinases
References
Ref 545400	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003114)
Ref 533452	Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93.
Ref 549592	US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT.
Ref 550162	EP patent application no. 2490711, A pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent).

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