| Drug General Information |
| Drug ID |
D0CZ3C
|
| Former ID |
DNC002612
|
| Drug Name |
2'-deoxyuridylic acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H13N2O8P
|
| Canonical SMILES |
C1C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)O)O
|
| InChI |
1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
|
| InChIKey |
JSRLJPSBLDHEIO-SHYZEUOFSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3656, 583802, 798022, 822266, 823444, 825213, 825214, 828144, 828145, 830224, 830228, 830235, 832005, 835128, 835849, 841407, 6436610, 7890996, 8144075, 8189480, 10322973, 10322974, 10322975, 10322976, 14772105, 17403862, 24698007, 24902352, 26707457, 26707458, 26707459, 26707460, 26709019, 26709021, 26711307, 26711587, 26711597, 26711599, 26711600, 26711628, 26711630, 26711632, 26712459, 26712460, 26717973, 29196043, 29211825, 43121904, 46391576, 46392291
|
| Target and Pathway |
| Target(s) |
Thymidylate synthase |
Target Info |
Inhibitor |
[1]
|
|---|
| Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Pyrimidine deoxyribonucleotides biosynthesis from CTP
|
|
Pyrimidine deoxyribonucleotides de novo biosynthesis
|
|
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
|
|
Superpathway of pyrimidine deoxyribonucleoside salvage
|
|
DTMP de novo biosynthesis (mitochondrial)
|
|
Pyrimidine deoxyribonucleosides salvage
|
|
KEGG Pathway
|
Pyrimidine metabolism
|
|
One carbon pool by folate
|
|
Metabolic pathways
|
|
PANTHER Pathway
|
De novo pyrimidine deoxyribonucleotide biosynthesis
|
|
Formyltetrahydroformate biosynthesisP02739:De novo pyrimidine deoxyribonucleotide biosynthesis
|
|
Pathway Interaction Database
|
E2F transcription factor network
|
|
PathWhiz Pathway
|
Pyrimidine Metabolism
|
|
Reactome
|
E2F mediated regulation of DNA replication
|
|
Pyrimidine biosynthesis
|
|
G1/S-Specific Transcription
|
|
WikiPathways
|
Trans-sulfuration and one carbon metabolism
|
|
Retinoblastoma (RB) in Cancer
|
|
One Carbon Metabolism
|
|
Integrated Pancreatic Cancer Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in leukocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
Metabolism of nucleotides
|
|
Fluoropyrimidine Activity
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
