Drug Information

Drug General Information
Drug ID
D0D1HW
Former ID
DAP000612
Drug Name
Anagrelide
Synonyms
Anagrelida; Anagrelidum; BL 416201; Agrylin (TN); Anagrelida [INN-Spanish]; Anagrelide [BAN:INN]; Anagrelide [INN:BAN]; Anagrelidum [INN-Latin]; Xagrid (TN); Anagrelide (INN/BAN); 6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on; 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one; 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one; 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
Drug Type
Small molecular drug
Indication Thrombocythemia [ICD9: 289.9; ICD10:D75.8] Approved [536361], [542121]
Therapeutic Class
Antithrombotic Agents
Company
Shire Phamaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C10H7Cl2N3O
InChI
InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
InChIKey
OTBXOEAOVRKTNQ-UHFFFAOYSA-N
CAS Number
CAS 68475-42-3
PubChem Compound ID
2182
PubChem Substance ID
5128700, 14774505, 14798804, 26755034, 29221360, 46508863, 49981497, 51091786, 57321189, 71822539, 74629579, 85341952, 91610578, 92308757, 92712546, 93166869, 99375712, 103202719, 103914916, 104299847, 124892336, 124954033, 126630074, 126668392, 128857870, 128857871, 134337903, 135039796, 136342475, 137005638, 137102173, 137263428, 140705858, 142334850, 152038761, 162178765, 163414816, 164788034, 164814571, 165222687, 172896975, 175266749, 175612207, 176484104, 178103691, 179116560, 179148387, 184545488, 184675310, 185984681
SuperDrug ATC ID
L01XX35
SuperDrug CAS ID
cas=068475423
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [536112]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542121(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7114).
Ref 536112Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med. 2005 Jul 7;353(1):33-45.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.