Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D2GL
|
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| Former ID |
DIB020396
|
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| Drug Name |
MPPG
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [538892] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C9H12NO5P
|
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| InChI |
InChI=1S/C9H12NO5P/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H2,13,14,15)
|
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| InChIKey |
PAONCRJPUQXPRW-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | mGlu6 receptor | Target Info | Antagonist | [543751] | |
| Metabotropic glutamate receptor 4 | Target Info | Antagonist | [525456] | ||
| Metabotropic glutamate receptor 7 | Target Info | Antagonist | [525945] | ||
| Metabotropic glutamate receptor 8 | Target Info | Antagonist | [534561] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| References | |||||
| Ref 525456 | Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. | ||||
| Ref 525945 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. | ||||
| Ref 534561 | Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. | ||||
| Ref 543751 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). | ||||
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