Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D2UA
|
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| Former ID |
DIB000835
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| Drug Name |
2-NAP
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| Synonyms |
N-(2-Naphthylsulfonyl)-L-aspartic acid 2-phenylethylamide sodium salt
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| Drug Type |
Small molecular drug
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| Indication | Gastrointestinal disease [ICD10:K00-K93] | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C22H22N2O5S
|
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| Canonical SMILES |
C1=CC=C(C=C1)CCNC(=O)C(CC(=O)O)NS(=O)(=O)C2=CC3=CC=CC=C<br />3C=C2
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| InChI |
1S/C22H22N2O5S/c25-21(26)15-20(22(27)23-13-12-16-6-2-1-3-7-16)24-30(28,29)19-11-10-17-8-4-5-9-18(17)14-19/h1-11,14,20,24H,12-13,15H2,(H,23,27)(H,25,26)/t20-/m0/s1
|
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| InChIKey |
VMYREBYTVVSDDK-FQEVSTJZSA-N
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| CAS Number |
CAS 141577-40-4
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Cholecystokinin receptor type A | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist. Br J Clin Pharmacol. 2007 May;63(5):618-22. Epub 2006 Oct 17. | ||||
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