Drug General Information
Drug ID	D0D2WX
Former ID	DNCL003573
Drug Name	1614235 + 2330672
Drug Type	Small molecular drug
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 1	[549464]
Company	GlaxoSmithKline
Structure
Formula	C21H28NO3+
PubChem Compound ID	1614235
Target and Pathway
Target(s)	Sodium/glucose cotransporter 1	Target Info	Modulator	[543973]
	Ileal bile acid transfer	Target Info	Modulator	[543982]
KEGG Pathway	Carbohydrate digestion and absorption
	Bile secretion
	Mineral absorptionhsa04976:Bile secretion
PathWhiz Pathway	Lactose Degradation
	Trehalose Degradation
Reactome	Hexose transport
	Na+-dependent glucose transporters
	Inositol transportersR-HSA-159418:Recycling of bile acids and salts
WikiPathways	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Metabolism of carbohydratesWP1788:Bile acid and bile salt metabolism
References
Ref 549464	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037723)
Ref 543973	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 915).
Ref 543982	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 960).

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