Drug Information

Drug General Information
Drug ID
D0D3DU
Former ID
DNC000933
Drug Name
Methotrexate Sodium
Synonyms
Abitrexate; Folex; Folex Pfs; Methotrexate Lpf; Methotrexate Preservative Free; Methotrexate Sodium; Methotrexate Sodium Preservative Free; Mexate; Mexate-aq; Mexate-aq Preserved; Trexall
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Approved [551871]
Discovery agent Investigative [468047]
Therapeutic Class
Anticancer Agents
Company
Hospira Inc
Structure
Download
2D MOL
Formula
C20H22N8O5
InChI
InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChIKey
FBOZXECLQNJBKD-ZDUSSCGKSA-N
CAS Number
CAS 142155-43-9
PubChem Compound ID
126941
PubChem Substance ID
5042, 67627, 585459, 585463, 602572, 826993, 831594, 835286, 836777, 837147, 3138774, 7847210, 7889076, 7979933, 8028432, 8029193, 8029470, 8149420, 10241686, 10321387, 11110523, 11113978, 11120366, 11120854, 11121342, 11335289, 11360528, 11364750, 11367312, 11369874, 11371593, 11374311, 11378039, 11447411, 11461500, 11466163, 11467283, 11484830, 11485885, 11488893, 11490313, 11492431, 11495650, 14760074, 14808762, 17404585, 22395177, 24897373, 24902354, 26680792
ChEBI ID
ChEBI:44185
SuperDrug ATC ID
L01BA01; L04AX03
SuperDrug CAS ID
cas=000059052
Target and Pathway
Target(s) DHFR Target Info Modulator [556264]
KEGG Pathway One carbon pool by folate
Folate biosynthesis
Metabolic pathways
PANTHER Pathway Tetrahydrofolate biosynthesis
Formyltetrahydroformate biosynthesis
Pathway Interaction Database E2F transcription factor network
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
WikiPathways Nucleotide Metabolism
Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Metabolism of water-soluble vitamins and cofactors
Metabolism of nitric oxide
Folate Metabolism
Fluoropyrimidine Activity
References
Ref 468047(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4815).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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