Drug General Information
Drug ID	D0D3FF
Former ID	DNC013720
Drug Name	2-(phenylethynyl)pyrimidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530217]
Structure		Download 2D MOL 3D MOL
Formula	C12H8N2
Canonical SMILES	C1=CC=C(C=C1)C#CC2=NC=CC=N2
InChI	1S/C12H8N2/c1-2-5-11(6-3-1)7-8-12-13-9-4-10-14-12/h1-6,9-10H
InChIKey	JGGFEZRQOSIEGG-UHFFFAOYSA-N
PubChem Compound ID	12490583
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[530217]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 530217	J Med Chem. 2009 Jul 23;52(14):4103-6.Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.
Ref 530217	J Med Chem. 2009 Jul 23;52(14):4103-6.Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.

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