Drug General Information
Drug ID	D0D3VA
Former ID	DNC001090
Drug Name	PAI-2
Drug Type	Small molecular drug
Indication	Discovery agent		Discontinued in Phase 2	[545764]
Structure		Download 2D MOL 3D MOL
Formula	C8H13NO3
Canonical SMILES	CCCC(=O)NC1CCOC1=O
InChI	1S/C8H13NO3/c1-2-3-7(10)9-6-4-5-12-8(6)11/h6H,2-5H2,1H3,(H,9,10)
InChIKey	VFFNZZXXTGXBOG-UHFFFAOYSA-N
PubChem Compound ID	443433
PubChem Substance ID	6100709, 10299316, 14772581, 24701441, 24846500, 36886749, 50466167, 57404388, 92297658, 104629966, 125335311, 125570984, 142062054, 144236649, 179316785, 223678505, 227068522, 248319607, 249903816
Target and Pathway
Target(s)	Urokinase-type plasminogen activator	Target Info	Inhibitor	[534979]
KEGG Pathway	NF-kappa B signaling pathway
	Complement and coagulation cascades
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Blood coagulation
	Plasminogen activating cascade
	CCKR signaling map ST
Pathway Interaction Database	Beta1 integrin cell surface interactions
	E2F transcription factor network
	Beta3 integrin cell surface interactions
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	amb2 Integrin signaling
	ATF-2 transcription factor network
	AP-1 transcription factor network
	Beta2 integrin cell surface interactions
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	FGF signaling pathway
Reactome	Dissolution of Fibrin Clot
WikiPathways	DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Complement and Coagulation Cascades
	Endochondral Ossification
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Blood Clotting Cascade
	Dissolution of Fibrin Clot
	Osteopontin Signaling
References
Ref 545764	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004611)
Ref 534979	Topological localization of plasminogen activator inhibitor type 2. Cytometry. 2000 May 1;40(1):32-41.

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