Drug General Information
Drug ID	D0D4JI
Former ID	DIB010786
Drug Name	SR-31747
Synonyms	SR-317417A
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Phase 2	[534643]
Company	Sanofi-aventis; Sanofi-Synthelabo
Structure		Download 2D MOL 3D MOL
Formula	C23H35Cl2N
Canonical SMILES	c1(c(ccc(c1)/C=C\CN(C1CCCCC1)CC)C1CCCCC1)Cl.Cl
PubChem Compound ID	6439330
Target and Pathway
Target(s)	Cholestenol delta-isomerase	Target Info	Modulator	[534643]
BioCyc Pathway	Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
	Cholesterol biosynthesis III (via desmosterol)
	Cholesterol biosynthesis I
	Superpathway of cholesterol biosynthesis
KEGG Pathway	Steroid biosynthesis
	Metabolic pathways
References
Ref 534643	Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.
Ref 534643	Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.

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