Drug Information

Drug General Information
Drug ID
D0D4YZ
Former ID
DCL001224
Drug Name
PSI-7977
Drug Type
Small molecular drug
Indication HCV genotypes 1-6 [ICD10:B17.1, B18.2] Approved [889440]
HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Phase 2 [551499]
Company
Gilead Sciences
Structure
Download
2D MOL

3D MOL
Formula
C22H29FN3O9P
Canonical SMILES
CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F<br />)O)OC3=CC=CC=C3
InChI
1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
InChIKey
TTZHDVOVKQGIBA-IQWMDFIBSA-N
PubChem Compound ID
45375808
PubChem Substance ID
93367218, 120288070, 123086722, 136350055, 141294064, 152258620, 160647455, 165245625, 172232459, 175428457, 178103940, 198982808, 206711582, 223715859, 228166432, 241383586, 242982572, 249625858, 249807077, 249816415, 251963215, 252155260, 252166959
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Hepatitis C virus NS5B polymerase Target Info Modulator [532651]
References
Ref 5514992011 Pipeline of Pharmasset.
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.

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