Drug Information

Drug General Information
Drug ID
D0D5DE
Former ID
DIB014787
Drug Name
ALPRENOXIME HYDROCHLORIDE
Synonyms
CDDD-1815; HGP-5; Alprenoxime hydrochloride < USAN >; 1-(2-Allylphenoxy)-3-(isopropylamino)-2-propanone oxime monohydrochloride; 1-[(1-Methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-2-propanone oxime monohydrochloride
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Discontinued in Phase 2 [545495]
Structure
Download
2D MOL

3D MOL
Formula
C15H23ClN2O2
Canonical SMILES
CC(C)NC\\C(=N/O)\\COc1ccccc1CC=C
InChI
1S/C15H22N2O2/c1-4-7-13-8-5-6-9-15(13)19-11-14(17-18)10-16-12(2)3/h4-6,8-9,12,16,18H,1,7,10-11H2,2-3H3/b17-14+
InChIKey
XFQFSSGNEFUEPA-SAPNQHFASA-N
CAS Number
CAS 121009-30-1
PubChem Compound ID
60729
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [529137]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545495Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003470)
Ref 529137Improved delivery through biological membranes. LVI. Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent. Pharm Res. 1991 Nov;8(11):1389-95.

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