| Drug General Information |
| Drug ID |
D0D5HQ
|
| Former ID |
DIB019097
|
| Drug Name |
K00024
|
| Synonyms |
indolocarbazole deriv. 4(d); K00024
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C20H10BrN3O2
|
| InChI |
InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26)
|
| InChIKey |
NMFKDDRQSNVETB-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
8036429, 10319100, 11062408, 15005679, 26758443, 39303411, 53800820, 57361305, 71826076, 74990922, 99302672, 103252800, 163121645, 163688393, 175607466, 178102573, 180372390, 204377875, 208265030, 218927893, 227610784, 243796737, 251961210
|
| Target and Pathway |
| Target(s) |
Cell division protein kinase 2 |
Target Info |
Inhibitor |
[2]
|
|---|
| Cell division protein kinase 4 |
Target Info |
Inhibitor |
[2]
|
| Cell division control protein 2 homolog |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
FoxO signaling pathway
|
|
Cell cycle
|
|
Oocyte meiosis
|
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Progesterone-mediated oocyte maturation
|
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Hepatitis B
|
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Measles
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Viral carcinogenesis
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Prostate cancer
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|
Small cell lung cancerhsa04110:Cell cycle
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Tight junction
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T cell receptor signaling pathway
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HTLV-I infection
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Pancreatic cancer
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Glioma
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Small cell lung cancer
|
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Non-small cell lung cancerhsa04110:Cell cycle
|
|
Gap junction
|
|
NetPath Pathway
|
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling PathwayNetPath_21:RANKL Signaling Pathway
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PANTHER Pathway
|
p53 pathway
|
|
p53 pathway feedback loops 2
|
|
Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by PRL
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p73 transcription factor network
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E2F transcription factor network
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ATR signaling pathway
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mTOR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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FOXM1 transcription factor network
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BARD1 signaling events
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|
p53 pathway
|
|
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Validated targets of C-MYC transcriptional activation
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ATF-2 transcription factor network
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Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
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PLK1 signaling events
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AP-1 transcription factor network
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Retinoic acid receptors-mediated signaling
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Reactome
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G0 and Early G1
|
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Activation of ATR in response to replication stress
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Regulation of APC/C activators between G1/S and early anaphase
|
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SCF(Skp2)-mediated degradation of p27/p21
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Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
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Processing of DNA double-strand break ends
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G2 Phase
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Meiotic recombination
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Factors involved in megakaryocyte development and platelet productionR-HSA-2559580:Oxidative Stress Induced Senescence
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Oncogene Induced Senescence
|
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RMTs methylate histone arginines
|
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Transcriptional regulation of white adipocyte differentiation
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Ubiquitin-dependent degradation of Cyclin D1
|
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Cyclin D associated events in G1
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Meiotic recombinationR-HSA-110056:MAPK3 (ERK1) activation
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E2F mediated regulation of DNA replication
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Cyclin B2 mediated events
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Golgi Cisternae Pericentriolar Stack Reorganization
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
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Phosphorylation of the APC/C
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Phosphorylation of Emi1
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Condensation of Prophase Chromosomes
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MASTL Facilitates Mitotic Progression
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Resolution of Sister Chromatid Cohesion
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Condensation of Prometaphase Chromosomes
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Regulation of PLK1 Activity at G2/M Transition
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Activation of NIMA Kinases NEK9, NEK6, NEK7
|
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Loss of Nlp from mitotic centrosomes
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Recruitment of mitotic centrosome proteins and complexes
|
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Loss of proteins required for interphase microtubule organization?from the centrosome
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Recruitment of NuMA to mitotic centrosomes
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Depolymerisation of the Nuclear Lamina
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Anchoring of the basal body to the plasma membrane
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MAPK6/MAPK4 signaling
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G1/S-Specific Transcription
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G2/M DNA replication checkpoint
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
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WikiPathways
|
DNA Damage Response
|
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ID signaling pathway
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DNA Replication
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G1 to S cell cycle control
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M/G1 Transition
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S Phase
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Meiotic Recombination
|
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Aryl Hydrocarbon Receptor
|
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ATM Signaling Pathway
|
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Retinoblastoma (RB) in Cancer
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Prostate Cancer
|
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
|
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Integrated Breast Cancer Pathway
|
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Integrated Cancer pathway
|
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Synthesis of DNA
|
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Regulation of DNA replication
|
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Mitotic G2-G2/M phases
|
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Mitotic G1-G1/S phases
|
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Factors involved in megakaryocyte development and platelet production
|
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Cell Cycle
|
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APC/C-mediated degradation of cell cycle proteins
|
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Cell Cycle Checkpoints
|
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miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
|
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Ovarian Infertility Genes
|
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PPAR Alpha Pathway
|
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Bladder Cancer
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
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TGF beta Signaling Pathway
|
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MAP kinase activation in TLR cascade
|
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RAF/MAP kinase cascade
|
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Mitotic Prophase
|
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Mitotic Prometaphase
|
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BMI1
|
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Regulation of Microtubule Cytoskeleton
|
|
miRNA Regulation of DNA Damage Response
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5950). |
|---|
| REF 2 | Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22;46(11):2027-30. |
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