Drug Information

Drug General Information
Drug ID
D0D8LQ
Former ID
DNC007924
Drug Name
1-(2-bromophenyl)-3-(4-cyano-2-hydroxyphenyl)urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528628]
Structure
Download
2D MOL

3D MOL
Formula
C14H10BrN3O2
Canonical SMILES
C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)C#N)O)Br
InChI
1S/C14H10BrN3O2/c15-10-3-1-2-4-11(10)17-14(20)18-12-6-5-9(8-16)7-13(12)19/h1-7,19H,(H2,17,18,20)
InChIKey
VIKJECVSALYBJB-UHFFFAOYSA-N
PubChem Compound ID
9949456
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Inhibitor [528628]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528628Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. Epub 2006 Dec 23.Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor.
Ref 528628Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. Epub 2006 Dec 23.Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.