Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D9AD
|
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| Former ID |
DIB013343
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| Drug Name |
YM-750
|
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| Synonyms |
ACAT inhibitors, Yamanouchi
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| Drug Type |
Small molecular drug
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Discontinued in Phase 1 | [1] | ||
| Company |
Yamanouchi Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C31H36N2O
|
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| Canonical SMILES |
C(=O)(Nc1c(cc(cc1C)C)C)N(Cc1cc2c(c3c(C2)cccc3)cc1)C1CCC<br />CCC1
|
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| CAS Number |
CAS 138046-43-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003090) | ||||
| REF 2 | Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008 Jan 2;82(1-2):79-84. Epub 2007 Nov 26. | ||||
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