Drug General Information
Drug ID	D0D9PH
Former ID	DIB008083
Drug Name	Small molecule 18a
Synonyms	Pim-1 kinase inhibitors (cancer); Pim-1 kinase inhibitors (cancer), Vertex
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543563]
Company	Vertex Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(nn2c(c1)nnc2c1cccc(c1)C(F)(F)F)N[C@H]1CC[C@@H](CC1)<br />O
Target and Pathway
Target(s)	Proto-oncogene pim-1	Target Info	Inhibitor	[543563]
KEGG Pathway	Jak-STAT signaling pathway
	MicroRNAs in cancer
	Acute myeloid leukemia
NetPath Pathway	IL9 Signaling Pathway
	IL5 Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	GMCSF-mediated signaling events
	Validated targets of C-MYC transcriptional activation
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	IL5-mediated signaling events
	IL3-mediated signaling events
	C-MYB transcription factor network
WikiPathways	Ectoderm Differentiation
	Hematopoietic Stem Cell Differentiation
References
Ref 543563	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).
Ref 543563	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).

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