Drug General Information
Drug ID	D0DH5X
Former ID	DNCL003828
Drug Name	MK-4618
Indication	Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81]		Phase 2	[523395]
Company	Merck
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Agonist	[549065]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523395	ClinicalTrials.gov (NCT01314872) A Study of the Efficacy and Safety of MK-4618 in Patients With Overactive Bladder (OAB) (MK-4618-008 AM3 EXT1[AM2]). U.S. National Institutes of Health.
Ref 549065	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031896)

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