Drug Information

Drug General Information
Drug ID
D0DV3O
Former ID
DAP001074
Drug Name
Epinastine
Synonyms
Epinastina; Epinastinum; Purivist; Epinastina [Spanish]; Epinastine [INN]; Epinastinum [Latin]; WAL 80; WAL 801; WAL 801CL; Elestat (TN); Epinastine (INN); Purivist (TN); Relestat (TN); WAL-80 Cl; (+-)-Epinastine; 3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine; 3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine; 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
Drug Type
Small molecular drug
Indication Allergic conjunctivitis [ICD9: 204.0, 372.0, 372.14, 995.3; ICD10:C91.0, H10, H10.45, T78.4] Approved [536119], [542186]
Therapeutic Class
Antihistamines
Company
Allergan Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C16H15N3
InChI
InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)
InChIKey
WHWZLSFABNNENI-UHFFFAOYSA-N
CAS Number
CAS 80012-43-7
PubChem Compound ID
3241
PubChem Substance ID
5173366, 8152057, 14847686, 29217549, 29222382, 46509056, 50065222, 50111706, 56464356, 57321677, 75376315, 81041126, 85209437, 85286058, 90340676, 92714612, 96024596, 103305708, 104022599, 104302939, 118313772, 125357916, 126629485, 126655288, 126684289, 129584096, 134338331, 135026263, 136912969, 137101854, 142087407, 152034622, 152253736, 160964094, 162176284, 164814672, 178103751, 179148544, 196106483, 206246277, 210279785, 210282108, 221672861, 223381334, 223435039, 223681981, 224278905, 226408729, 251912269, 251916574
ChEBI ID
ChEBI:51037
SuperDrug ATC ID
R06AX24; S01GX10
SuperDrug CAS ID
cas=080012437
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537248]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref 542186(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7176).
Ref 537248Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo. Mediators Inflamm. 2009;2009:738038. Epub 2009 Apr 9.

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