Drug Information

Drug General Information
Drug ID
D0E1QP
Former ID
DNC005896
Drug Name
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527917]
Structure
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2D MOL

3D MOL
Formula
C13H14N2O
Canonical SMILES
C1CC(C2=C(C1)C3=CC=CC=C3N2)C(=O)N
InChI
1S/C13H14N2O/c14-13(16)10-6-3-5-9-8-4-1-2-7-11(8)15-12(9)10/h1-2,4,7,10,15H,3,5-6H2,(H2,14,16)
InChIKey
YMLOFDJHJSQCSN-UHFFFAOYSA-N
PubChem Compound ID
4262314
Target and Pathway
Target(s) NAD-dependent deacetylase sirtuin-1 Target Info Inhibitor [527917]
KEGG Pathway FoxO signaling pathway
AMPK signaling pathway
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Signaling events mediated by HDAC Class III
E2F transcription factor network
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
FoxO family signaling
Regulation of Androgen receptor activity
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
Regulation of HSF1-mediated heat shock response
Circadian Clock
WikiPathways Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Androgen receptor signaling pathway
References
Ref 527917J Med Chem. 2005 Dec 15;48(25):8045-54.Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Ref 527917J Med Chem. 2005 Dec 15;48(25):8045-54.Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

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