Drug Information

Drug General Information
Drug ID
D0E3OF
Former ID
DAP000770
Drug Name
Warfarin
Synonyms
Brumolin; Choice; Coumadin; Coumafen; Coumafene; Coumaphen; Coumaphene; Coumarins; Coumefene; Dethmor; Dethnel; Kumader; Kumadu; Kumatox; Kypfarin; Maveran; Panwarfin; Prothromadin; RAX; Ratorex; Ratoxin; Ratron; Rattentraenke; Rattunal; Rodafarin; Rosex; Sofarin; Solfarin; Warfarat; Warfarina; Warfarine; Warfarinum; Warficide; Zoocoumarin; Arab Rat Death; Arab rat deth; Coumafene [French]; Dicusat E; Eastern states duocide; Fasco fascrat powder; Maag Rattentod Cum; Mouse pak; Ratron G; Rattenstreupulver Neu Schacht; Rattenstreupulver new schacht; Rodafarin C; Rodex blox; Sorexa plus; Temus W; Twin light rat away; Vampirinip II; Vampirinip iii; Warfarin Q; Warfarin plus; Warfarin plus [discontinued]; Zoocoumarin [Netherlands and USSR]; Zoocoumarin [Russian]; CBKinase1_000192; CBKinase1_012592; Latka 42; Latka 42 [Czech]; PS104_SUPELCO; WARF compound 42; Warf 10; Warf 42; Athrombine-K; CO-Rax; Choice (TN); Coumadin (TN); D-Con; Frass-Ratron; Jantoven (TN); Liqua-tox; Mar-Frin; Marevan (TN); Place-pax; Rac-Warfarin; Rat & mice bait; Rat-Gard; Rat-Kill; Rat-Mix; Rat-Ola; Rat-Trol; Ratten-Koederrohr; Ro-Deth; Rough & ready mouse mix; Tox-hid; Waran (TN); Warfarin (INN); Warfarin (and salts of); Warfarin [BSI:ISO]; Warfarin [INN:BAN]; Warfarin(R); Warfarina [INN-Spanish]; Warfarine [INN-French]; Warfarine [ISO-French]; Warfarinum [INN-Latin]; Cov-R-Tox; Martin's mar-frin; Rat-B-gon; Rat-a-way; Rats-no-more; Spray-trol brand roden-trol; Rat-o-cide #2; Warfarin titrated to an INR of 2.5-3.0; W.A.R.F. 42; (-)-Warfarin; (S)-Warfarin; 200 coumarin
Drug Type
Small molecular drug
Indication Atrial fibrillation [ICD9: 272, 427.31; ICD10:E78, I48] Approved [536186], [541933]
Therapeutic Class
Anticoagulants
Company
Pharmaceutical Research Assoc Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H16O4
InChI
InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
InChIKey
PJVWKTKQMONHTI-UHFFFAOYSA-N
CAS Number
CAS 81-81-2
PubChem Compound ID
54678486
PubChem Substance ID
4702, 107893, 601310, 5231431, 7980889, 8149584, 8154328, 10536481, 11131065, 11142173, 11335619, 11360858, 11363088, 11365650, 11368212, 11371626, 11374040, 11376374, 11461830, 11484606, 11488751, 11490399, 11492196, 11494008, 14825580, 24869276, 24890636, 24899091, 26611979, 26680140, 26748308, 26748309, 26754489, 29225641, 42685079, 46504711, 47217039, 47291357, 47589215, 47885639, 48035388, 48334766, 48416701, 48421807, 49956144, 50085958, 50123544, 51071804, 53787517, 53788585
ChEBI ID
ChEBI:10034
SuperDrug ATC ID
B01AA03
SuperDrug CAS ID
cas=000081812
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Vitamin K epoxide reductase complex subunit 1 Target Info Inhibitor [536520]
KEGG Pathway Ubiquinone and other terpenoid-quinone biosynthesis
PathWhiz Pathway Vitamin K Metabolism
Coagulation
WikiPathways PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
References
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
Ref 541933(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6853).
Ref 536520Oral anticoagulation and pharmacogenetics: importance in the clinical setting. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.

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