Drug General Information
Drug ID	D0E5CI
Former ID	DNC011435
Drug Name	8-Piperazin-1-yl-imidazo[1,2-a]pyrazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526778]
Structure		Download 2D MOL 3D MOL
Formula	C10H13N5
Canonical SMILES	C1CN(CCN1)C2=NC=CN3C2=NC=C3
InChI	1S/C10H13N5/c1-5-14(6-2-11-1)9-10-13-4-8-15(10)7-3-12-9/h3-4,7-8,11H,1-2,5-6H2
InChIKey	NSHLOJVJEGEMSF-UHFFFAOYSA-N
PubChem Compound ID	131268
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[526778]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[526778]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Endothelin Pathways
	AMPK Signaling
References
Ref 526778	J Med Chem. 1992 Oct 16;35(21):3845-57.Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.
Ref 526778	J Med Chem. 1992 Oct 16;35(21):3845-57.Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.

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