Drug General Information
Drug ID	D0E5KK
Former ID	DIB004191
Drug Name	MGluR2 PAMs
Synonyms	MGluR2 PAMs (CNS disorders); MGluR2 PAMs (CNS disorders), Pfizer
Indication	Central nervous system disease [ICD10:G00-G99]		Investigative	[543747]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	FC(F)(Oc1cc(c([C@H]2[C@H](CN(Cc3nc4ncccc4n3C)CC2)C)cc1)<br />F)F
Target and Pathway
Target(s)	Metabotropic glutamate receptor 2	Target Info	Modulator	[543747]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Cocaine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group II pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543747	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).
Ref 543747	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).

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