Drug Information

Drug General Information
Drug ID
D0E5VP
Former ID
DIB006234
Drug Name
KF-66490
Synonyms
K-34; KF-66490; PDE 4 inhibitors (dermatitis/rheumatoid arthritis); PDE 4 inhibitors (dermatitis/rheumatoid arthritis), Kyowa Hakko Kirin
Drug Type
Small molecular drug
Indication Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Investigative [529747]
Company
Kyowa Hakko Kirin Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C18H22N4O5
Canonical SMILES
CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N5CC5)OC)N4C)N
InChI
1S/C18H22N4O5/c1-8-12(19)15(24)11-9(7-27-17(25)21-4-5-21)18(26-3)16-10(20(16)2)6-22(18)13(11)14(8)23/h9-10,16H,4-7,19H2,1-3H3
InChIKey
FZLZUGFFXNJCRD-UHFFFAOYSA-N
PubChem Compound ID
281833
PubChem Substance ID
423374, 6719177, 41301497, 76558961, 104459884, 162968727
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [529747]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [529747]
Type IV phosphodiesterase Target Info Inhibitor [529747]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathway
References
Ref 529747Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol. 2009 Jan;9(1):55-62.
Ref 529747Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol. 2009 Jan;9(1):55-62.

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