Drug General Information
Drug ID	D0E5ZP
Former ID	DNC007196
Drug Name	7-(trifluoromethyl)-1H-indole-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528749]
Structure		Download 2D MOL 3D MOL
Formula	C9H4F3NO2
Canonical SMILES	C1=CC2=C(C(=C1)C(F)(F)F)NC(=O)C2=O
InChI	1S/C9H4F3NO2/c10-9(11,12)5-3-1-2-4-6(5)13-8(15)7(4)14/h1-3H,(H,13,14,15)
InChIKey	MXLDJTXXAYVWDF-UHFFFAOYSA-N
PubChem Compound ID	604575
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528749]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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