Drug Information

Drug General Information
Drug ID
D0E6LC
Former ID
DNC001363
Drug Name
SPR-210
Drug Type
Small molecular drug
Indication Diabetic complication [ICD10:E08-E13] Terminated [545343]
Structure
Download
2D MOL

3D MOL
Formula
C18H11F3N2O3S2
Canonical SMILES
CC1=C2C(=CC=C1)SC(C(=O)N2C3=NC4=C(C(=CC(=C4S3)F)F)F)CC(<br />=O)O
InChI
1S/C18H11F3N2O3S2/c1-7-3-2-4-10-15(7)23(17(26)11(27-10)6-12(24)25)18-22-14-13(21)8(19)5-9(20)16(14)28-18/h2-5,11H,6H2,1H3,(H,24,25)
InChIKey
ZVSDXQXCVBUOHA-UHFFFAOYSA-N
CAS Number
CAS 143162-65-6
PubChem Compound ID
132542
PubChem Substance ID
10243142, 15353729, 29310664, 57344186, 76980521, 104377689, 126437429, 134340555, 135089382, 227839632
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [537904]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 545343Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002923)
Ref 537904Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats. Jpn J Pharmacol. 1994 Feb;64(2):115-24.

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