Drug Information

Drug General Information
Drug ID
D0E7YK
Former ID
DNC014636
Drug Name
(R)-5-Amino-3-(4-chloro-phenyl)-pentanoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525508]
Structure
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2D MOL

3D MOL
Formula
C11H14ClNO2
Canonical SMILES
C1=CC(=CC=C1C(CCN)CC(=O)O)Cl
InChI
1S/C11H14ClNO2/c12-10-3-1-8(2-4-10)9(5-6-13)7-11(14)15/h1-4,9H,5-7,13H2,(H,14,15)/t9-/m1/s1
InChIKey
QXAGSDSDBMVSQR-SECBINFHSA-N
PubChem Compound ID
10491829
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Inhibitor [525508]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 525508J Med Chem. 1999 Jun 3;42(11):2053-9.Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoicacid.
Ref 525508J Med Chem. 1999 Jun 3;42(11):2053-9.Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoicacid.

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