Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E8CZ
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| Former ID |
DCL000695
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| Drug Name |
Amibegron
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| Synonyms |
SR 58611; Amibegron (USAN/INN); Ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder; Obesity; Type 2 diabetes [ICD9: 250, 250.00, 250.02, 278, 296, 296.2, 296.3; ICD10:E08-E13, E11, E66, F30-F39, F32, F33] | Preclinical | [536580], [541023] | ||
| Major depressive disorder; Severe mood disorders [ICD9: 296, 296.2, 296.3; ICD10:F30-F39, F32, F33] | Discontinued in Phase 3 | [536580], [541023] | |||
| Company |
Sanofi-Aventis; Eli Lilly
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| Structure |
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Download2D MOL |
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| Formula |
C22H26ClNO4
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| InChI |
InChI=1S/C22H26ClNO4/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3/t19-,21-/m0/s1
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| InChIKey |
RDJQCOBTKKAQAH-FPOVZHCZSA-N
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| CAS Number |
CAS 121524-08-1
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Beta-3 adrenergic receptor | Target Info | Agonist | [536580] | |
| References | |||||
| Ref 536580 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
| Ref 541023 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 568). | ||||
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