Drug General Information
Drug ID	D0E8UJ
Former ID	DIB012755
Drug Name	BW-1370U87
Synonyms	1-Ethylphenoxathiin-10,10-dioxide
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Discontinued in Phase 1	[545298]
Structure		Download 2D MOL 3D MOL
Formula	C14H12O3S
Canonical SMILES	CCC1=C2C(=CC=C1)OC3=CC=CC=C3S2(=O)=O
InChI	1S/C14H12O3S/c1-2-10-6-5-8-12-14(10)18(15,16)13-9-4-3-7-11(13)17-12/h3-9H,2H2,1H3
InChIKey	HQSRQKBSOOZLHH-UHFFFAOYSA-N
PubChem Compound ID	126111
PubChem Substance ID	10241495, 14823743, 29305763, 57341647, 80909863, 103260610, 103922723, 104362924, 128099599, 135081383, 162279637, 162787524, 224986959, 229872685
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] A	Target Info	Inhibitor	[533985], [551871]
BioCyc Pathway	Superpathway of tryptophan utilization
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
	Serotonin degradation
	Superpathway of melatonin degradation
	Melatonin degradation II
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Histidine Metabolism
	Tyrosine Metabolism
	Glycine and Serine Metabolism
Reactome	Norepinephrine Neurotransmitter Release Cycle
WikiPathways	SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	Oxidative Stress
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
	Neurotransmitter Release Cycle
	Neurotransmitter Clearance In The Synaptic Cleft
	Serotonin Transporter Activity
References
Ref 545298	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002739)
Ref 533985	Preclinical and early clinical studies with BW 1370U87, a reversible competitive monoamine oxidase-A inhibitor. Clin Neuropharmacol. 1993;16 Suppl 2:S25-33.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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