Drug Information

Drug General Information
Drug ID
D0EI9B
Former ID
DIB018945
Drug Name
BAY 367620
Synonyms
BAY 36-7620; BAY36-7620; BAY-367620
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538857]
Structure
Download
2D MOL
Formula
C19H18O2
InChI
InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1
InChIKey
CVIRWLJKDBYYOG-MJGOQNOKSA-N
PubChem Compound ID
9903757
PubChem Substance ID
14872920, 15222151, 24185706, 45975427, 47734230, 49958826, 79680617, 85789099, 103562067, 104088253, 135649980, 142030235, 162023502, 172649790, 198954462, 208265316, 226546257, 241375968, 248228125, 249617588, 252156564
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Modulator (allosteric modulator) [526030]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538857(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1381).
Ref 526030BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol Pharmacol. 2001 May;59(5):965-73.

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