Drug General Information
Drug ID	D0EK6P
Former ID	DNC000006
Drug Name	(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535639]
Structure		Download 2D MOL 3D MOL
Formula	C6H10N2O4
Canonical SMILES	C1C(NCC1(C(=O)O)N)C(=O)O
InChI	1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
InChIKey	XZFMJVJDSYRWDQ-AWFVSMACSA-N
PubChem Compound ID	5310984
PubChem Substance ID	7978587, 11056185, 15120503, 24276926, 26744280, 26752104, 39340717, 57359309, 75240015, 90343729, 91744841, 99223623, 103216567, 103949275, 114154977, 117518359, 118315296, 126594410, 127305654, 127305655, 127305656, 127305657, 127305658, 129762234, 131301572, 131400559, 134339562, 134339599, 135635420, 135649704, 137264922, 141428213, 143439230, 151993633, 152055475, 162449345, 164830906, 176224839, 180666389, 204433876, 223594614, 226522464, 241182231, 251875150
Target and Pathway
Target(s)	Metabotropic glutamate receptor 2	Target Info	Agonist	[535639]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Cocaine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group II pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 535639	Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats. Behav Neurosci. 2002 Dec;116(6):1075-83.
Ref 535639	Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats. Behav Neurosci. 2002 Dec;116(6):1075-83.

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