Drug Information

Drug General Information
Drug ID
D0EV1I
Former ID
DNC009281
Drug Name
C-014C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529524]
Structure
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2D MOL

3D MOL
Formula
C22H32N4O2
Canonical SMILES
COC1=C(C=C2C(=C1)C(=NC(=N2)NC3CCCC3)NC4CCCCCC4)OC
InChI
1S/C22H32N4O2/c1-27-19-13-17-18(14-20(19)28-2)25-22(24-16-11-7-8-12-16)26-21(17)23-15-9-5-3-4-6-10-15/h13-16H,3-12H2,1-2H3,(H2,23,24,25,26)
InChIKey
HZBKRPBMAVNOCZ-UHFFFAOYSA-N
PubChem Compound ID
44561260
Target and Pathway
Target(s) C-Cchemokine receptor type 4 Target Info Inhibitor [529524]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 529524Bioorg Med Chem. 2008 Jul 15;16(14):7021-32. Epub 2008 May 20.Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines.
Ref 529524Bioorg Med Chem. 2008 Jul 15;16(14):7021-32. Epub 2008 May 20.Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines.

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