TTD | Drug: D0EV7U

Drug General Information
Drug ID	D0EV7U
Former ID	DIB019967
Drug Name	GSK-LSD1
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543006]
Structure		Download 2D MOL
Formula	C14H20N2
InChI	InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
InChIKey	BASFYRLYJAZPPL-UONOGXRCSA-N
PubChem Compound ID	71522234
PubChem Substance ID	163515243, 239848352, 249565921
Target and Pathway
Target(s)	Lysine specific histone demethylase 1	Target Info	Inhibitor	[543682]
Pathway Interaction Database	Notch signaling pathway
	Coregulation of Androgen receptor activity
	Notch-mediated HES/HEY network
Reactome	HDACs deacetylate histones
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Factors involved in megakaryocyte development and platelet production
WikiPathways	Androgen receptor signaling pathway
References
Ref 543006	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8241).
Ref 543682	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2669).

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Drug Information