Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0EW6H
|
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| Former ID |
DIB020245
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| Drug Name |
LTC4
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| Synonyms |
leukotriene C4
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C30H47N3O9S
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| InChI |
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
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| InChIKey |
GWNVDXQDILPJIG-NXOLIXFESA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5241, 4266071, 7978470, 8144736, 8616294, 26756768, 39289599, 47439963, 50111412, 53787291, 57357762, 76781864, 92126168, 103591345, 113853360, 126523876, 127302679, 127302680, 127302681, 127302682, 127302683, 127302684, 127302685, 135651512, 137005676, 137240026, 138355248, 179293089, 184584916, 198947983, 237822003, 250135036, 252455506, 252467942
|
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| Target and Pathway | |||||
| Target(s) | Cysteinyl leukotriene receptor 1 | Target Info | Agonist | [2] | |
| GPR17 | Target Info | Agonist | [3] | ||
| Leukotriene CysLT2 receptor | Target Info | Agonist | [4] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| IL4 Signaling Pathway | |||||
| IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway | |||||
| IL3 Signaling Pathway | |||||
| Pathway Interaction Database | Endothelinsendothelinpathway:Endothelins | ||||
| Reactome | Leukotriene receptors | ||||
| G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors | |||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3354). | ||||
| REF 2 | Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93. | ||||
| REF 3 | The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. Epub 2006 Sep 21. | ||||
| REF 4 | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8. | ||||
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