Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0EZ2W
|
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| Former ID |
DNC014552
|
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| Drug Name |
CR-2345
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C26H37Cl3N4O3
|
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| Canonical SMILES |
CN1CCN(CC1)C(=O)CCC(C(=O)N2CCC3(CCCC3)CC2)NC(=O)C4=CC(=<br />CC(=C4)Cl)Cl.Cl
|
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| InChI |
1S/C26H36Cl2N4O3.ClH/c1-30-12-14-31(15-13-30)23(33)5-4-22(29-24(34)19-16-20(27)18-21(28)17-19)25(35)32-10-8-26(9-11-32)6-2-3-7-26;/h16-18,22H,2-15H2,1H3,(H,29,34);1H
|
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| InChIKey |
FXORBQJCRPUVDJ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cholecystokinin receptor type A | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Biological properties of (R)-4-benzamido-5-oxopentanoic basic derivatives as CCK-antagonists, Bioorg. Med. Chem. Lett. 3(5):861-866 (1993). | ||||
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