Drug Information

Drug General Information
Drug ID
D0F0ZK
Former ID
DIB008820
Drug Name
KB-003
Synonyms
KB-002; Anti-GM-CSF mAb (autoimmune disease), Ludwig/KaloBios; Anti-GM-CSF mAb (inflammatory disease/rheumatoid arthritis/asthma), KaloBios
Drug Type
Antibody
Indication Severe asthma [ICD9: 493; ICD10:J45] Phase 2 [522819]
Company
Kalobios pharmaceuticals
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor Target Info [551919]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Salmonella infection
Amoebiasis
HTLV-I infection
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
Alpha9 beta1 integrin signaling events
AP-1 transcription factor network
Calcium signaling in the CD4+ TCR pathway
Syndecan-2-mediated signaling events
Regulation of retinoblastoma protein
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways Cytokines and Inflammatory Response
Hematopoietic Stem Cell Differentiation
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 522819ClinicalTrials.gov (NCT00995449) Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 551919US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.

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