Drug Information

Drug General Information
Drug ID
D0F2NF
Former ID
DIB004302
Drug Name
GSK-958108
Indication Premature ejaculation [ICD9: 302.75; ICD10:F52.4] Phase 1 [522300]
Company
GlaxoSmithKline plc
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [551853]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522300ClinicalTrials.gov (NCT00664365) FTIH Study With GSK958108. U.S. National Institutes of Health.
Ref 551853Clinical pipeline report, company report or official report of GlaxoSmithKline.

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