Drug Information

Drug General Information
Drug ID
D0F2WP
Former ID
DCL000650
Drug Name
TAK-385
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Phase 2 [540954], [548740]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C29H27F2N7O5S
InChI
InChI=1S/C29H27F2N7O5S/c1-36(2)14-19-24-26(39)38(22-12-13-23(42-3)34-33-22)29(41)37(15-18-20(30)6-5-7-21(18)31)27(24)44-25(19)16-8-10-17(11-9-16)32-28(40)35-43-4/h5-13H,14-15H2,1-4H3,(H2,32,35,40)
InChIKey
AOMXMOCNKJTRQP-UHFFFAOYSA-N
PubChem Compound ID
10348973
PubChem Substance ID
15360452, 22711606, 33982018, 79383172, 134451836, 136354668, 139946408, 163642570, 172919602, 178102221, 198967092, 202535644, 227061017, 248341989, 252216360
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [551717]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540954(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5586).
Ref 548740Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028257)
Ref 551717Clinical pipeline report, company report or official report of Takeda (2009).

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