Drug Information
Drug General Information | |||||
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Drug ID |
D0F3AR
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Former ID |
DNC012652
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Drug Name |
4-((Z)-1-Naphthalen-1-yl-propenyl)-1H-imidazole
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C16H14N2
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Canonical SMILES |
CC=C(C1=CC=CC2=CC=CC=C21)C3=CN=CN3
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InChI |
1S/C16H14N2/c1-2-13(16-10-17-11-18-16)15-9-5-7-12-6-3-4-8-14(12)15/h2-11H,1H3,(H,17,18)/b13-2-
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InChIKey |
VDVBKYMIYSQNPM-SILLCRNTSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Alpha-1B adrenergic receptor | Target Info | Inhibitor | [1] | |
Alpha-1D adrenergic receptor | Target Info | Inhibitor | [1] | ||
Alpha-1A adrenergic receptor | Target Info | Inhibitor | [1] | ||
KEGG Pathway | Calcium signaling pathway | ||||
cGMP-PKG signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Adrenergic signaling in cardiomyocytes | |||||
Vascular smooth muscle contraction | |||||
Salivary secretionhsa04020:Calcium signaling pathway | |||||
AMPK signaling pathway | |||||
Salivary secretion | |||||
NetPath Pathway | IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway | ||||
PANTHER Pathway | Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway | ||||
Pathway Interaction Database | LPA receptor mediated events | ||||
Reactome | Adrenoceptors | ||||
G alpha (q) signalling events | |||||
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors | |||||
G alpha (12/13) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
Calcium Regulation in the Cardiac Cell | |||||
GPCRs, Class A Rhodopsin-like | |||||
Vitamin D Receptor Pathway | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
AMPK SignalingWP58:Monoamine GPCRs | |||||
GPCRs, OtherWP58:Monoamine GPCRs | |||||
Endothelin Pathways | |||||
AMPK Signaling | |||||
References | |||||
REF 1 | J Med Chem. 1996 Jul 19;39(15):3001-13.Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine. | ||||
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