Drug General Information
Drug ID	D0F3CA
Former ID	DNC007255
Drug Name	3,4-dichloroisocoumarin
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528555]
Structure		Download 2D MOL 3D MOL
Formula	C9H4Cl2O2
Canonical SMILES	C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl
InChI	1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
InChIKey	SUGXUUGGLDCZKB-UHFFFAOYSA-N
PubChem Compound ID	1609
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[528555]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 528555	Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. Epub 2006 Dec 4.Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
Ref 528555	Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. Epub 2006 Dec 4.Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.