Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F3FC
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| Former ID |
DIB007845
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| Drug Name |
GSK-650394
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| Synonyms |
SGK-1 inhibitor (prostate cancer), GlaxoSmithKline
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| Drug Type |
Small molecular drug
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| Indication | Prostate cancer [ICD9: 185; ICD10:C61] | Investigative | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H22N2O2
|
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| InChI |
InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
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| InChIKey |
WVSBGSNVCDAMCF-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
56372317, 57539305, 103691849, 104137542, 135684976, 135698891, 161004290, 163125605, 172096672, 172650544, 174006394, 177749675, 180371701, 198978264, 203081890, 204371603, 208265528, 210275191, 210280830, 223427127, 223704823, 229755473, 241376526, 242078818, 247483342, 249565720, 249617914, 251963080, 252151146, 252157366, 252160262, 252450683, 252471858, 252543666
|
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| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Sgk1 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | FoxO signaling pathway | ||||
| PI3K-Akt signaling pathway | |||||
| Aldosterone-regulated sodium reabsorption | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| FSH Signaling Pathway | |||||
| IL2 Signaling Pathway | |||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Glucocorticoid receptor regulatory network | |||||
| mTOR signaling pathway | |||||
| FoxO family signaling | |||||
| Class I PI3K signaling events | |||||
| Reactome | Stimuli-sensing channels | ||||
| WikiPathways | Insulin Signaling | ||||
| Iron uptake and transport | |||||
| FSH signaling pathway | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040). | ||||
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