| Drug General Information |
| Drug ID |
D0F4CD
|
| Former ID |
DIB019859
|
| Drug Name |
Flt-3 inhibitor II
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C17H12N2O3
|
| InChI |
InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
|
| InChIKey |
NIMIWWQLOGNYHD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16704450, 23713465, 26758702, 53800920, 80361177, 99302677, 103488347, 104071350, 134343796, 163125973, 163688141, 175607406, 178102594, 180372392, 204372561, 208265127, 228358004, 244165283
|
| Target and Pathway |
| Target(s) |
FL cytokine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Cytokine-cytokine receptor interaction
|
|
Hematopoietic cell lineage
|
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Pathways in cancer
|
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Transcriptional misregulation in cancer
|
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Acute myeloid leukemia
|
|
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
|
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Ras signaling pathway
|
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Rap1 signaling pathway
|
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Calcium signaling pathway
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PI3K-Akt signaling pathway
|
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Focal adhesion
|
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Gap junction
|
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Regulation of actin cytoskeleton
|
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HTLV-I infection
|
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MicroRNAs in cancer
|
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Glioma
|
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Prostate cancer
|
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Melanoma
|
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Central carbon metabolism in cancer
|
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Choline metabolism in cancer
|
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PANTHER Pathway
|
Angiogenesis
|
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PDGF signaling pathway
|
|
Pathway Interaction Database
|
Signaling events mediated by PTP1B
|
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Beta3 integrin cell surface interactions
|
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S1P3 pathway
|
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Nectin adhesion pathway
|
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Signaling events mediated by TCPTP
|
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SHP2 signaling
|
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S1P1 pathway
|
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
|
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PDGF receptor signaling network
|
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Reactome
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PIP3 activates AKT signaling
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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RAF/MAP kinase cascade
|
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WikiPathways
|
Regulation of Actin Cytoskeleton
|
|
MAPK Signaling Pathway
|
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Osteoblast Signaling
|
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Focal Adhesion
|
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PIP3 activates AKT signaling
|
|
PDGF Pathway
|
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Signaling Pathways in Glioblastoma
|
|
Signaling by PDGF
|
| References |
| REF 1 | J Med Chem. 2006 Jun 1;49(11):3101-15.Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. |
|---|
