Drug Information

Drug General Information
Drug ID
D0F4MI
Former ID
DIB013836
Drug Name
TAK-075
Synonyms
TAK-075; Calcium-sensing receptor antagonists (osteoporosis); Calcium-sensing receptor antagonists (osteoporosis), Takeda
Drug Type
Small molecular drug
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Investigative [543874]
Company
Takeda Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Formula
C36H46N4O4S
Canonical SMILES
C(C(CC)(NC(=O)c1c(nn2C(C)(C)C[C@@H](Nc12)c1ccccc1)C)c1c<br />cc(cc1)CC)C.S(=O)(=O)(c1ccc(cc1)C)O
PubChem Compound ID
50915156
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Antagonist [543874]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 543874(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 54).
Ref 543874(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 54).

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