TTD | Drug: D0F5QL

Drug General Information
Drug ID	D0F5QL
Former ID	DIB019920
Drug Name	GM-109
Synonyms	GM109; GM 109
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538932]
Structure		Download 2D MOL
Formula	C31H43N5O5
InChI	InChI=1S/C31H43N5O5/c1-31(2,3)22-17-21(12-13-26(22)37)19-25-29(40)34-16-14-27(38)33-15-8-7-11-24(30(41)36-25)35-28(39)23(32)18-20-9-5-4-6-10-20/h4-6,9-10,12-13,17,23-25,37H,7-8,11,14-16,18-19,32H2,1-3H3,(H,33,38)(H,34,40)(H,35,39)(H,36,41)/t23-,24-,25-/m0/s1
InChIKey	RRXAKVUZGASTMY-SDHOMARFSA-N
PubChem Compound ID	9850904
PubChem Substance ID	14813005, 16164012, 24146774, 45273228, 80629914, 135652173, 242583028
Target and Pathway
Target(s)	Motilin receptor	Target Info	Antagonist	[526253]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538932	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1466).
Ref 526253	Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin. J Med Chem. 2002 Jan 31;45(3):670-5.

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Drug Information