| Drug General Information |
| Drug ID |
D0F6CD
|
| Former ID |
DNC003553
|
| Drug Name |
SEROTONIN
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H12N2O
|
| InChI |
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
|
| InChIKey |
QZAYGJVTTNCVMB-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4041, 803912, 3249485, 6492753, 7978601, 8144285, 8153195, 11111288, 11111289, 11120330, 11120818, 11121306, 11121741, 11122221, 11362866, 11364882, 11365428, 11367444, 11367990, 11370006, 11370943, 11370944, 11373045, 11373591, 11375606, 11376152, 11378175, 11466509, 11467629, 11485998, 15120541, 26737386, 26754231, 26754232, 26754233, 29224259, 47662064, 47662065, 47662066, 47662067, 47662068, 47810539, 47810540, 47885201, 47885202, 47885203, 47959524, 48110239, 48259014, 48334252
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1B receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[3]
|
| 5-hydroxytryptamine 4 receptor |
Target Info |
Inhibitor |
[3]
|
| 5-hydroxytryptamine 5A receptor |
Target Info |
Inhibitor |
[4]
|
| 5-hydroxytryptamine 1D receptor |
Target Info |
Inhibitor |
[5]
|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Inhibitor |
[6]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[7]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[7]
|
| 5-hydroxytryptamine receptor 3A |
Target Info |
Inhibitor |
[8]
|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Inhibitor |
[9]
|
| Adenosine A3 receptor |
Target Info |
Inhibitor |
[10]
|
| 5-hydroxy-tryptamine 3B receptor |
Target Info |
Inhibitor |
[8]
|
| 5-hydroxytryptamine 7 receptor |
Target Info |
Inhibitor |
[4]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
|
Serotonergic synapsehsa04024:cAMP signaling pathway
|
|
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
|
Serotonergic synapsehsa04726:Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Inflammatory mediator regulation of TRP channelshsa04726:Serotonergic synapsehsa04014:Ras signaling pathway
|
|
Calcium signaling pathway
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 4 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (i) signalling eventsR-HSA-975298:Ligand-gated ion channel transportR-HSA-390666:Serotonin receptors
|
|
G alpha (q) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
|
Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
|
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
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GPCR downstream signalingWP58:Monoamine GPCRs
|
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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SIDS Susceptibility Pathways
|
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GPCR downstream signaling
|
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
|
|
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
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Iron uptake and transportWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
GPCR downstream signalingWP80:Nucleotide GPCRs
|
|
GPCRs, OtherWP2670:Iron uptake and transportWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5). |
|---|
| REF 2 | J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. |
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| REF 3 | J Nat Prod. 2006 Oct;69(10):1421-4.Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
|---|
| REF 4 | J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. |
|---|
| REF 5 | J Med Chem. 2008 Jun 26;51(12):3609-16. Epub 2008 May 29.Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide. |
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| REF 6 | J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. |
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| REF 7 | J Med Chem. 2009 Nov 12;52(21):6946-50.Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. |
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| REF 8 | J Med Chem. 1999 May 6;42(9):1556-75.Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. |
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| REF 9 | Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. Epub 2005 Oct 27.Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. |
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| REF 10 | J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
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