Drug Information

Drug General Information
Drug ID
D0F6YK
Former ID
DCL000133
Drug Name
Implitapide
Synonyms
Implitapide [INN]; (2S)-2-cyclopentyl-2-[3-[(2,4-dimethylpyrido[2,3-b]indol-9-yl)methyl]phenyl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Phase 2 [521593]
Company
MRL international
Structure
Download
2D MOL

3D MOL
Formula
C35H37N3O2
Canonical SMILES
CC1=CC(=NC2=C1C3=CC=CC=C3N2CC4=CC(=CC=C4)C(C5CCCC5)C(=O<br />)NC(CO)C6=CC=CC=C6)C
InChI
1S/C35H37N3O2/c1-23-19-24(2)36-34-32(23)29-17-8-9-18-31(29)38(34)21-25-11-10-16-28(20-25)33(27-14-6-7-15-27)35(40)37-30(22-39)26-12-4-3-5-13-26/h3-5,8-13,16-20,27,30,33,39H,6-7,14-15,21-22H2,1-2H3,(H,37,40)/t30-,33-/m0/s1
InChIKey
AMNXBQPRODZJQR-DITALETJSA-N
PubChem Compound ID
5745206
PubChem Substance ID
39540274, 50076575, 50562907, 57365058, 114110604, 135140727, 137267541, 160708752, 175426863, 198946096, 227839194
Target and Pathway
Target(s) Microsomal triglyceride transfer protein, large subunit Target Info Inhibitor [536042], [536210], [536980]
KEGG Pathway Fat digestion and absorption
Reactome Chylomicron-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 521593ClinicalTrials.gov (NCT00080132) Implitapide in Patients With Hypertriglyceridemia (HTG) on Maximal, Concurrent Triglyceride-Lowering Therapy. U.S. National Institutes of Health.
Ref 536042Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull. 2005 Feb;28(2):247-52.
Ref 536210Lipid-lowering drugs. Cell Mol Life Sci. 2006 May;63(10):1165-78.
Ref 536980Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr Atheroscler Rep. 2009 Jan;11(1):67-70.

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