Drug Information

Drug General Information
Drug ID
D0F7BV
Former ID
DNC012635
Drug Name
1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533374]
Structure
Download
2D MOL

3D MOL
Formula
C19H22N2O2
Canonical SMILES
C1=CC=C(C=C1)CCNCC(COC2=CC=CC3=C2C=CN3)O
InChI
1S/C19H22N2O2/c22-16(13-20-11-9-15-5-2-1-3-6-15)14-23-19-8-4-7-18-17(19)10-12-21-18/h1-8,10,12,16,20-22H,9,11,13-14H2
InChIKey
MDPRLCKPDFRPJV-UHFFFAOYSA-N
PubChem Compound ID
13626879
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Inhibitor [533374]
Beta-3 adrenergic receptor Target Info Inhibitor [533374]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 533374J Med Chem. 1986 Aug;29(8):1524-7.Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols.
Ref 533374J Med Chem. 1986 Aug;29(8):1524-7.Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.