Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F8CC
|
||||
| Former ID |
DIB019087
|
||||
| Drug Name |
CD666
|
||||
| Synonyms |
CD-666; CD 666
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H28O3
|
||||
| InChI |
InChI=1S/C24H28O3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,21,25H,13-14H2,1-4H3,(H,26,27)/b12-7+
|
||||
| InChIKey |
QCSYBKHFYYISTQ-KPKJPENVSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Retinoic acid receptor gamma | Target Info | Agonist | [2] | |
| Retinoic acid receptor beta | Target Info | Agonist | [2] | ||
| Retinoic acid receptor alpha | Target Info | Agonist | [2] | ||
| KEGG Pathway | Pathways in cancer | ||||
| Small cell lung cancer | |||||
| Non-small cell lung cancerhsa05200:Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Acute myeloid leukemia | |||||
| Pathway Interaction Database | Retinoic acid receptors-mediated signaling | ||||
| Reactome | Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | ||||
| Nuclear Receptors in Lipid Metabolism and Toxicity | |||||
| Mesodermal Commitment Pathway | |||||
| Endoderm Differentiation | |||||
| Nuclear ReceptorsWP716:Vitamin A and Carotenoid Metabolism | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Adipogenesis | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2652). | ||||
| REF 2 | Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83. | ||||
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