Drug Information

Drug General Information
Drug ID
D0F8YO
Former ID
DNC005401
Drug Name
2-[3-(1-Hydroxy-propyl)-phenyl]-propionic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527602]
Structure
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2D MOL

3D MOL
Formula
C12H16O3
Canonical SMILES
CCC(C1=CC=CC(=C1)C(C)C(=O)O)O
InChI
1S/C12H16O3/c1-3-11(13)10-6-4-5-9(7-10)8(2)12(14)15/h4-8,11,13H,3H2,1-2H3,(H,14,15)
InChIKey
HTWFANVWNDWYRH-UHFFFAOYSA-N
PubChem Compound ID
9964424
Target and Pathway
Target(s) High affinity interleukin-8 receptor A Target Info Inhibitor [527602]
High affinity interleukin-8 receptor B Target Info Inhibitor [527602]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infectionhsa04060:Cytokine-cytokine receptor interaction
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR1-mediated signaling eventsil8cxcr2_pathway:IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Differentiation Pathway
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
GPCRs, Other
References
Ref 527602J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
Ref 527602J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

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