TTD | Drug: D0FP9N

Drug General Information
Drug ID	D0FP9N
Former ID	DIB013560
Drug Name	P11187
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 1	[524321]
Company	Piramal enterprises
Target and Pathway
Target(s)	GPR40	Target Info	Modulator	[544438]
KEGG Pathway	Insulin secretion
Reactome	G alpha (q) signalling events
Reactome	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways	GPCRs, Class A Rhodopsin-like
	Incretin Synthesis, Secretion, and Inactivation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524321	ClinicalTrials.gov (NCT01874366) Determination of Safety,Tolerability,Pharmacokinetics,Food Effect& Pharmacodynamics of Single & Multiple Doses of P11187. U.S. National Institutes of Health.
Ref 544438	Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists. Front Endocrinol (Lausanne) 2014; 5: 137.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information